Vice President of Clinical Development

About Every Cure -

Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. Our vision is a world where no patients suffer when there’s a treatment sitting at their local pharmacy that could be repurposed to treat them.  We are filling a gap left by the current biomedical system, which doesn’t pursue new uses for cheap, old drugs. Through artificial intelligence technologies, collaboration with healthcare professionals, and patient advocacy, Every Cure is dedicated to unlocking the full potential of existing medicines to treat every disease and every patient we possibly can. Inspired by Every Cure’s co-founders' work repurposing drugs for Castleman disease and other rare diseases, Every Cure is advancing repurposed treatments for neglected diseases and has been featured in New York Times, USA Today, and Good Morning America. Led by a talented leadership team and an outstanding Board of Directors, Every Cure is supported through funding from leading philanthropic organizations like Chan Zuckerberg Initiative and Elevate Prize Foundation and a federal contract with ARPA-H. 

Our approach -

• AI-Powered Identification: We use advanced artificial intelligence to analyze the world’s biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. This cutting-edge technology enables us to explore new therapeutic possibilities efficiently. 
• Open-Source Commitment: We are dedicated to making our predictive pipeline open-source, fostering collaboration and transparency within the scientific community and unlocking the potential for discovering new treatments. 
• High-Impact Focus: We prioritize drug repurposing opportunities that can benefit neglected patient communities, ensuring our efforts address the most pressing needs. 
• Rigorous Validation: Promising opportunities are thoroughly validated through laboratory and clinical studies to confirm their efficacy and safety before advancing to broader application. 
• Global Access: We are committed to ensuring that new cures are accessible to all patients. 

The Vice President of Clinical Development will be responsible for leading Every Cure’s clinical research strategy and driving the advancement of our most promising drug repurposing opportunities through clinical validation and patient impact. This position plays a critical role in translating early-stage discoveries into real-world treatments by overseeing a diverse portfolio of studies, including natural history research, real-world evidence generation, and interventional clinical trials. Reporting to the President, the Vice President of Clinical Development will serve as the senior medical leader on the executive team, collaborating closely with the tech and scientific teams to prioritize high-impact programs and ensure rigorous, ethical execution. The ideal candidate will bring deep expertise in clinical trial design and execution, a proven track record in clinical development and/or medical affairs, and a passion for accelerating cures for patients in need. 

How you will make an impact - 

• Clinical Strategy & Organizational Leadership 
  • Set the vision and strategic direction for Every Cure’s clinical research and development portfolio. 
  • Serve as the medical executive on the leadership team, advising on clinical strategy, program development, and organizational growth. 
  • Collaborate with the VP of Discovery to select and advance drug repurposing opportunities with the highest potential patient impact. 
• Program Oversight & Clinical Execution 
  • Lead the design and implementation of clinical research studies, including real-world evidence studies, natural history registries, and clinical trials. 
  • Ensure programs are scientifically rigorous, ethically sound, and compliant with regulatory standards. 
  • Make data-driven decisions on program continuation, optimization, or sunsetting. 
• Portfolio Management & Resource Allocation 
  • Apply risk-adjusted and impact-oriented frameworks to prioritize and manage a diverse drug repurposing pipeline. 
  • Oversee resource allocation across therapeutic areas to ensure optimal use of funding, talent, and time. 
• Collaboration with AI & Technical Teams 
  • Provide clinical insight to inform the development and refinement of Every Cure’s AI discovery platform. 
  • Support model interpretability and validation by helping to design studies, when needed, that test and improve predictive outputs. 
• Stakeholder Engagement & Dissemination 
  • Represent Every Cure in public, scientific, and regulatory forums as a credible and inspiring medical leader. 
  • Cultivate partnerships with CROs, academic institutions, advocacy organizations, and regulatory bodies. 
  • Support dissemination efforts to ensure successful translation of findings into accessible treatments, including publications and healthcare outreach. 
• Team Building & Development 
  • Build and lead a high-performing team of clinicians and clinical researchers. 
  • Establish clear roles, standards, and a culture of excellence, integrity, and collaboration. 
  • Promote continuous learning through mentoring and development opportunities. 

What you bring to the team - 

• Education 
  • MD, MD/PhD, or PharmD required. 
• Experience 
  • 5+ years of experience in clinical research and portfolio management, with a strong track record of leading clinical trials. 
  • Demonstrated leadership in building and managing teams. 
  • Expertise in clinical trial design, protocol development, drug development, and decision-making. 
  • Experience conducting Phase 2 and/or Phase 3 trials required. 
  • Experience working on drug products that have achieved regulatory approval. 
  • Experience working with rare diseases is a plus. 
  • Prior leadership in cross-functional clinical strategy. 
• Skills 
  • Deep knowledge of clinical research methods, real-world evidence generation, and regulatory requirements. 
  • Ability to translate complex data into strategic decisions and patient-facing outcomes. 
  • Comfort working with technical and computational teams in a collaborative environment. 
  • Exceptional communication and relationship-building skills with internal and external stakeholders. 
  • Strategic thinker with a strong bias toward impact, execution, and urgency. 
  • Passion for Every Cure’s mission and a high level of adaptability to thrive in a startup setting. 

Compensations & Benefits - 

• Your paycheck: Competitive salary based on experience, ranging from $275,000 - $325,000 annually. 
• Health and wellness: Comprehensive plans with medical, dental, and vision coverage, plus a Flexible Spending Account (FSA) for eligible healthcare expenses. 
• Future nest egg: A 403(b)-retirement plan with an employer match of 3.5% helps you save for your future. 
• Relax and recharge: Generous time off, including paid time off, sick time, and paid holidays. 
• We have you covered: Comprehensive paid leave for family and medical needs, ensuring you have the support you need during important times. 

This role is based in Cambridge, MA, with an expectation of minimum 3 days per week in office.  

Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws.